5-HTP 100mg

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Support for mood regulation + sleep

  • 5-HTP increases serotonin levels in the brain
  • Healthy sleeping patterns
  • Oral doses are well absorbed into the blood stream

5-HTP (5-hydroxytryptophan) is produced in the body from the amino acid tryptophan and is involved in nervous system health.1 It is a precursor to serotonin, a neurotransmitter involved in mood regulation, sleeping patterns, appetite, sexuality, and emotional states such as anger and aggression.2,3 5-HTP increases serotonin levels in the brain, which can help promote a calm mood and healthy sleep patterns.4

Unlike tryptophan, 5-HTP can easily cross the blood-brain barrier, making it effective for increasing serotonin levels in the central nervous system. Oral doses of 5-HTP are well-absorbed into the blood stream because it is not affected by other amino acids in digestion and it does not need a specific transport molecule.5

Vitamin B6 works with 5-HTP to create serotonin.6 If you are taking a B vitamin supplement, such as our B-Complex, you may wish to take the two products at the same time to optimize effectiveness. 

Other Ingredients:
 Rice flour and Cellulose (capsules).
If you are currently taking antidepressant medication please consult a physician prior to use. May cause drowsiness.
 Take one or more capsule(s) daily, preferably on an empty stomach. To aid in sleep, take at bedtime.

TRANSCEND‘s  5-HTP, 100 mg contains 60 vegetarian capsules per bottle.

  1. Shaw K, Turner J, Del Mar C."Tryptophan and 5-hydroxytryptophan for depression." Cochrane Database Syst Rev. 2002;(1):CD003198.

  2. Caspi N, Modai I, Barak P, Waisbourd A, Zbarsky H, Hirschmann S, Ritsner M. (2001 Mar). "Pindolol augmentation in aggressive schizophrenic patients: a double-blind crossover randomized study". Int Clin Psychopharmacol. 16(2): 111-5.

  3. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R."Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene." Science. 2003 Jul 18;301(5631):386-9.

  4. Wurtman RJ, Hefti F, Melamed E (1980). "Precursor control of neurotransmitter synthesis". Pharmacol. Rev. 32 (4): 315-35.

  5. Birdsall TC."5-Hydroxytryptophan: a clinically-effective serotonin precursor." Altern Med Rev. 1998 Aug;3(4):271-80.

  6. Jpn. J. Pharmacol. 32 (5): 803-11."Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats." Rahman MK, Nagatsu T, Sakurai T, Hori S, Abe M, Matsuda M (1982).


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