What is NAD?
NAD, or nicotinamide adenine dinucleotide, is a molecule found in every cell in the human body. Its core purpose is to help the mitochondria – the ‘powerhouse' of the cell, convert food into the energy. Additionally, NAD is required to “turn off” genes implicated in accelerating aging processes.
That's where TRU NIAGEN® comes in. The key ingredient in TRU NIAGEN® is NIAGEN® nicotinamide riboside (NR)— a cutting-edge form of vitamin B3 proven to significantly increase NAD levels.
The metabolism of nicotinamide riboside is unique from that of more common forms of vitamin B3, nicotinamide and nicotinic acid (niacin).
"NAD+ is one of the critical components of the Krebs cycle, the biochemical pathway that creates ATP; the body’s energy source.
Increasing NAD levels can translate into increased energy, mental clarity and focus, memory, and a general feeling of youthfulness."
– Terry Grossman, M.D.
TRU NIAGEN® & Healthy Aging.
NR supplementation increases NAD+, which activates several enzymes critical for health, like:
- CD38, a receptor involved in glucose-induced insulin secretion
- Sirtuins, an anti-aging enzymes
- PARPs, which repair damaged DNA
NR accomplishes this by stimulating mitochondrial biogenesis and improving mitochondrial health. Therefore, NR supplementation supports tissues that are heavily reliant on the mitochondria for energy, like our liver, nervous system, heart and muscles.
Benefits of NAD
NAD is essential to supporting many aspects of healthy aging:
- Increases cellular metabolism and energy production
- Maintains healthy cholesterol levels already within the normal range
- NAD supports muscle function, including maintenance of muscle mass
- Helps maintain health, longer
Mechanism of Action
The primary role of NR, as well as NA and NAM, is to serve
as precursors of the essential coenzyme nicotinamide adenine dinucleotide (NAD).
- NR is transported directly into cells via nucleoside transporters6, where it is converted to NAD through a distinct, two-step biosynthetic pathway.
- NR raises intracellular NAD levels with superior pharmacokinetics compared to NA and NAM.7