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  • Maintains proper cell function
  • Supports liver health
  • Promotes a healthy cardiovascular system
  • May reduce homocysteine levels

Methylation is a critical biological process involved in DNA repair and the production of beneficial compounds in the body such as SAMe and methionine. Unhealthy nutrition and lifestyle choices can dampen rmethylation, but supplementing with Trimethylglycine (TMG) can help facilitate methylation.

TMG is a methyl donor, meaning that it carries and donates methyl molecules to assist this essential chemical process in the body.1 Methyl donation is also vital to maintaining proper liver function. TMG is also involved in detoxification and cellular reproduction.

Research indicates that supplementing with TMG also supports healthy homocysteine levels.2,3,4 The body uses the methyl donation function of TMG to convert homocysteine to methionine, a beneficial amino acid. Elevated homocysteine levels have been linked to a higher risk of heart attack, stroke, peripheral arterial disease, bone fractures and Alzheimer's disease. A simple blood test is available to measure your homocysteine level and we recommend discussing this with your healthcare provider. Reducing red meat intake while increasing plant-based foods can also help lower elevated homocysteine levels.5

TMG also helps support healthy kidney function due to its role in the manufacture of carnitine, which has been studied for its effect on protecting the kidneys from oxidative stress.6,7


Other Ingredients: 

Microcrystalline Cellulose, Hydroxypropyl Cellulose, Vegetarian Coating, Stearic Acid (vegetable source), Croscarmellose Sodium and Magnesium Stearate (vegetable source).

Not manufactured with: Animal products, starch, artificial colors,
flavors or preservatives.


For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children. Keep the bottle tightly closed at all times in between usage. Keep the freshness packet in bottle. This product is very sensitive to moisture/humidity which may affect product stability.


TMG (Trimethylglycine)is known to facilitate methylation processes. Methylation is a normal biological process that is critical for DNA repair, liver detoxification mechanisms, lipid metabolism, and the production of SAMe. It is also an important step in the conversion of homocysteine, a damaging amino acid, into a more friendly amino acid, methionine. Supplementation with TMG has been shown in clinical and non-clinical studies to support healthy homocysteine levels already within normal range.*

Suggested Use: 
As a dietary supplement, take 1 tablet 1 to 3 times daily, preferably with food.

TRANSCEND's TMG contains 100 tablets per bottle.


  1. Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review].
  2. Schwab U, Törrönen A,, Meririnne E, Saarinen M, Alfthan G, Aro A, Uusitupa M. "Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans." J Nutr. 2006 Jan;136(1):34-8.
  3. Olthof MR, Verhoef P. "Effects of betaine intake on plasma homocysteine concentrations and consequences for health." Curr Drug Metab. 2005 Feb;6(1):15-22.
  4. Schwab U, Törrönen A,, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. "Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects." Am J Clin Nutr. 2002 Nov;76(5):961-7.
  5. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].
  6. Chambers ST. "Betaines: their significance for bacteria and the renal tract." Clin Sci1995;88:25-7.
  7. Ustundag S, Sen S, Yalcin O, Ciftci S, Demirkan B, Ture M. "L-Carnitine ameliorates glycerol-induced myoglobinuric acute renal failure in rats." Ren Fail. 2009;31(2):124-33.


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